|
Diabetic Neuropathies
|
0.520 |
AlteredExpression
|
group |
BEFREE |
Nonetheless, there are changes in the expression of insulin receptor during the progress of diabetic neuropathy, suggesting that this disorder begins before high glucose blood levels are established.
|
30742965 |
2019 |
|
Diabetic Neuropathies
|
0.520 |
Biomarker
|
group |
CTD_human |
Early changes in insulin receptor signaling and pain sensation in streptozotocin-induced diabetic neuropathy in rats.
|
18331706 |
2008 |
|
Diabetic Neuropathies
|
0.520 |
Biomarker
|
group |
BEFREE |
Here, we created an insulin resistant SC by deleting both insulin receptor (INSR) and insulin-like growth factor receptor 1 (IGF1R), to determine the role of this signaling pathway in development and response to injury in order to understand SC defects in DN.
|
31758725 |
2020 |
|
Diabetic Neuropathies
|
0.520 |
Biomarker
|
group |
RGD |
Early changes in insulin receptor signaling and pain sensation in streptozotocin-induced diabetic neuropathy in rats.
|
18331706 |
2008 |
|
Drug abuse
|
0.300 |
Biomarker
|
group |
CTD_human |
Genome wide association for addiction: replicated results and comparisons of two analytic approaches.
|
20098672 |
2010 |
|
Drug Use Disorders
|
0.300 |
Biomarker
|
group |
CTD_human |
Genome wide association for addiction: replicated results and comparisons of two analytic approaches.
|
20098672 |
2010 |
|
Lung diseases
|
0.300 |
Biomarker
|
group |
CTD_human |
Prenatal administration of retinoic acid upregulates insulin-like growth factor receptors in the nitrofen-induced hypoplastic lung.
|
21433279 |
2011 |
|
Lung diseases
|
0.300 |
Biomarker
|
group |
CTD_human |
Insulin receptor is downregulated in the nitrofen-induced hypoplastic lung.
|
20438933 |
2010 |
|
Substance Use Disorders
|
0.300 |
Biomarker
|
group |
CTD_human |
Genome wide association for addiction: replicated results and comparisons of two analytic approaches.
|
20098672 |
2010 |
|
Substance-Related Disorders
|
0.300 |
Biomarker
|
group |
CTD_human |
Genome wide association for addiction: replicated results and comparisons of two analytic approaches.
|
20098672 |
2010 |
|
Diabetic Polyneuropathies
|
0.300 |
Biomarker
|
group |
CTD_human |
Early changes in insulin receptor signaling and pain sensation in streptozotocin-induced diabetic neuropathy in rats.
|
18331706 |
2008 |
|
Drug Dependence
|
0.300 |
Biomarker
|
group |
CTD_human |
Genome wide association for addiction: replicated results and comparisons of two analytic approaches.
|
20098672 |
2010 |
|
Liver neoplasms
|
0.270 |
AlteredExpression
|
group |
BEFREE |
Additionally, we show that plasma levels of cleaved IR reflect IR isoform A expression levels in liver tumors, which prompts us to propose that the measurement of circulating cleaved IR may assist hepatic cancer detection and management.
|
29610518 |
2018 |
|
Liver neoplasms
|
0.270 |
AlteredExpression
|
group |
BEFREE |
Only very high concentrations of insulin-like growth factor I and human proinsulin can compete for the insulin receptor binding and suppress HBsAg production, this suggests that insulin may act through its receptor binding to suppress HBsAg expression in human hepatoma Hep3B cells.
|
2475498 |
1989 |
|
Liver neoplasms
|
0.270 |
Biomarker
|
group |
RGD |
Additionally, we show that plasma levels of cleaved IR reflect IR isoform A expression levels in liver tumors, which prompts us to propose that the measurement of circulating cleaved IR may assist hepatic cancer detection and management.
|
29610518 |
2018 |
|
Liver neoplasms
|
0.270 |
Biomarker
|
group |
BEFREE |
We next studied HTC-IR(Delta485-599) cells, which overexpress a mutant IR with a deletion in the alpha-subunit connecting domain that does not undergo autophosphorylation in response to insulin binding.
|
11574415 |
2001 |
|
Liver neoplasms
|
0.270 |
AlteredExpression
|
group |
BEFREE |
The ability of leptin to augment liver IR activation and PTP1B expression was also observed in vitro in human hepatoma cells (HepG2).
|
14976221 |
2004 |
|
Liver neoplasms
|
0.270 |
Biomarker
|
group |
RGD |
Mitogenic insulin receptor-A is overexpressed in human hepatocellular carcinoma due to EGFR-mediated dysregulation of RNA splicing factors.
|
23633480 |
2013 |
|
Liver neoplasms
|
0.270 |
AlteredExpression
|
group |
BEFREE |
Insulin receptor mRNA levels and insulin binding activity were reduced in HepG2 cultured at lower glucose concentrations.
|
2543399 |
1989 |
|
Liver neoplasms
|
0.270 |
AlteredExpression
|
group |
BEFREE |
Failure to replace complete medium resulted in growth arrest of HepG2 cells and a six- to sevenfold increase in insulin-receptor mRNA due to the prolongation of insulin-receptor mRNA half-life.
|
1849849 |
1991 |
|
Liver neoplasms
|
0.270 |
GeneticVariation
|
group |
BEFREE |
We have now constructed a human insulin receptor mutant in which 3 residues in this sequence were altered (Thr-Cys-Pro-Pro-Pro-Tyr-Tyr-His-Phe-Gln-Asp to Thr-Cys-Pro-Arg-Arg-Tyr-Tyr-Asp-Phe-Gln-Asp) and have expressed this mutant in rat hepatoma (HTC) cells.
|
2550426 |
1989 |
|
Diabetes Mellitus
|
0.200 |
AlteredExpression
|
group |
BEFREE |
Importantly, this phenotype was reversible (i.e., discontinuation of Dox treatment led to INSR re-expression and remission of diabetes symptoms).
|
19017805 |
2008 |
|
Diabetes Mellitus
|
0.200 |
GeneticVariation
|
group |
BEFREE |
The "T" allele of the His1085His polymorphism in the INSR gene shows significant protection against diabetes.
|
22775283 |
2012 |
|
Diabetes Mellitus
|
0.200 |
Biomarker
|
group |
BEFREE |
Rodents with tissue-specific knockout of the insulin receptor in the β-cell (βIRKO) show reduced first-phase glucose-stimulated insulin secretion (GSIS) and with aging develop glucose intolerance and diabetes, phenotypically similar to the process seen in human T2D.
|
22928576 |
2012 |
|
Diabetes Mellitus
|
0.200 |
Biomarker
|
group |
BEFREE |
The purpose of this study was to introduce the foreskin as a novel model to examine developmental programming in human neonates, particularly in regard to adipogenesis and insulin receptor signaling, major contributors to age-associated diseases such as obesity and diabetes.
|
28034763 |
2017 |